Ph.D
Dr. Toshiharu Shinoka, MD, PhD, is a pediatric cardiovascular surgeon and Director of the Cardiovascular Tissue Engineering Program at Nationwide Children’s Hospital. He is also a Professor of Surgery at The Ohio State University.
He pioneered the first successful implantation of tissue-engineered blood vessels in human infants and continues to advance bioengineered vascular grafts for congenital heart surgery. His clinical focus is on congenital heart anomalies and his research centers on tissue engineering, regenerative medicine, and vascular biology.
Director, Cardiovascular Tissue Engineering Program, Nationwide Children’s Hospital
Visiting Professor, Tokyo Women’s Medical University & University of Tokushima
Editorial board member of multiple scientific journals
Reviewer for NIH, ERC, and other grant agencies
Numerous invited lectures worldwide on vascular tissue engineering
Shinoka T, Imai Y, et al. Autologous cell-seeded biodegradable vascular grafts for pediatric cardiac surgery. Nature Medicine, 2001; 7(5): 520–523.
Landmark study — first in-human application of tissue-engineered vascular grafts in children.
Shinoka T, Breuer CK, et al. Clinical application of tissue-engineered vascular grafts in congenital heart surgery. The Journal of Thoracic and Cardiovascular Surgery, 2005; 129(6): 1330–1338.
Expanded clinical series validating autologous bone marrow cell–seeded grafts.
Miyachi H, Tara S, Hibino N, Breuer CK, Shinoka T. Development of tissue-engineered vascular grafts for use in congenital heart surgery. Tissue Engineering Part A, 2011; 17(3-4): 541–549.
Key preclinical validation of biodegradable scaffolds.
Sugiura T, Yi T, Tara S, Nakayama H, Kurobe H, Lee YU, Hibino N, Breuer CK, Shinoka T. Novel tissue-engineered vascular graft with highly porous sponge-type scaffold as a small-diameter arterial graft. The Journal of Thoracic and Cardiovascular Surgery, 2016; 152(4): 1384–1393.
Reinhardt JW, Lee YU, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Thrombotic remodeling drives early luminal neotissue formation in tissue-engineered vascular grafts. Acta Biomaterialia, 2018; 77: 89–102.
Matsuzaki Y, Miyamoto S, Miyachi H, Iwaki R, Shoji T, Blum K, Chang Y, Kelly J, Reinhardt J, Breuer CK, Shinoka T. Development of an off-the-shelf heparin-eluting tissue-engineered arterial graft. Biomaterials, 2019; 210: 52–63.
Lawson JH, Niklason LE, Shinoka T, et al. Evaluation of tissue-engineered human acellular vessels as Blalock–Taussig–Thomas shunts in juvenile primate models. Biomaterials, 2021; 275: 120921.
Wang Z, Mithieux SM, Vindin H, Liu L, Matsuzaki Y, Yi T, Blum KM, Pham NTH, Hawkett BS, Shinoka T, Breuer CK, Weiss AS. Rapid regeneration of a neoartery with elastic lamellae in a tropoelastin–polyglycerol sebacate small-diameter vascular graft. Acta Biomaterialia, 2022; 138: 145–156.
Kitsuka T, Matsuzaki Y, Iwaki R, Reinhardt J, Ulziibayar A, Hama R, Kelly J, Breuer CK, Shinoka T. Tropoelastin contributes to small-caliber tissue-engineered vascular graft performance. Regenerative Biomaterials, 2022; 9(6): rbac092.
